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[Apolipoproteins. Structure, function and pathological changes].

G Luc, G Turpin, J L De Gennes

    Annales De Medecine Interne
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    This review covers main apolipoproteins (A, B, C, E), detailing their structure and function in lipoprotein metabolism. It highlights how abnormalities in these proteins can cause lipid level disorders, impacting clinical practice.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Clinical Medicine

    Context:

    • Apolipoproteins are crucial protein components of lipoproteins.
    • Lipoprotein metabolism is essential for lipid transport and homeostasis.
    • Dysregulation of apolipoproteins is linked to various lipid disorders.

    Purpose:

    • To review current knowledge on major apolipoproteins (A, B, C, E).
    • To describe the structure and metabolic roles of these apolipoproteins.
    • To discuss the clinical implications of apolipoprotein abnormalities.

    Summary:

    • The review details the structure and function of apolipoproteins A, B, C, and E in lipoprotein metabolism.
    • It examines recent findings on structural and metabolic alterations in apolipoproteins.

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  • These changes are often associated with hyperlipoproteinemia or hypolipoproteinemia.

    • Impact:

    • Understanding apolipoprotein structure and function aids in diagnosing and managing lipid disorders.
    • Current techniques allow for the practical application of apolipoprotein knowledge in clinical settings.
    • This review provides insights into the clinical relevance of apolipoproteins.