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Oncogenes: clues to carcinogenesis

C R Bartram

    European Journal of Pediatrics
    |January 1, 1984
    PubMed

    Insights

    Cellular oncogenes (c-onc) are involved in normal cell growth and can cause cancer when activated. Viral oncogenes (v-onc) derived from cellular versions can also trigger tumor formation by altering cell genes.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Cancer Research

    Background:

    • Recombinant DNA techniques have identified cellular oncogenes (c-onc) with transforming potential.
    • Oncogenes regulate normal cell differentiation and proliferation, often through tyrosine phosphorylation.
    • Activated oncogenes are found in human tumors, and their DNA can transform normal cells.

    Purpose of the Study:

    • To review the role of oncogenes in cancer research.
    • To discuss the activation mechanisms and implications of oncogenes in carcinogenesis.
    • To highlight the link between oncogenes and chromosomal aberrations in neoplasms.

    Main Methods:

    • Review of recombinant DNA techniques and their application in oncogene discovery.
    • Analysis of oncogene function in normal cell processes.
    • Examination of oncogene activation in human tumors and transfection assays.
    • Discussion of viral oncogenes (v-onc) and their origins.

    Main Results:

    • Oncogenes, both cellular (c-onc) and viral (v-onc), play a critical role in cell transformation and cancer development.
    • Activation of oncogenes can occur through increased gene dosage or altered protein products.
    • The presence of oncogenes near chromosomal breakpoints in certain cancers underscores their significance.

    Conclusions:

    • Oncogenes are crucial genetic elements in the development of cancer.
    • Understanding oncogene activation is key to unraveling carcinogenesis.
    • The study emphasizes the importance of oncogenes in various human neoplasms.

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