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Cutaneous allergy to human (recombinant DNA) insulin
JAMA
|March 16, 1984
Summary
Patients with systemic allergy to porcine insulin may also react to human insulin (recombinant DNA) insulin. Managing insulin allergy with animal insulins proved effective for these cases, suggesting human insulin isn't universally suitable.
Area of Science:
- Endocrinology
- Allergology
- Immunology
Background:
- Systemic allergic reactions to porcine insulin can necessitate alternative treatments.
- Human insulin (recombinant DNA) is often considered for patients with porcine insulin allergy.
Observation:
- Two patients with a history of systemic allergic reactions to porcine insulin were evaluated.
- Both patients exhibited significant cutaneous reactivity to both porcine and human insulin (recombinant DNA) via titration.
Findings:
- Cutaneous allergy to human insulin (recombinant DNA) was observed in both patients.
- Allergy management using animal insulins was successful for both individuals.
Implications:
- Human insulin (recombinant DNA) may not be effective for all patients experiencing systemic insulin allergy.
- Alternative insulin formulations, such as animal insulins, remain crucial for managing specific cases of insulin allergy.