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Reversible tubular lesion in pregnancy-induced hypertension detected by urinary beta 2-microglobulin
Serum and urine beta 2-microglobulin concentrations were measured in 17 primigravidas with mild pregnancy-induced hypertension and nine normotensive control patients matched for gestational age. Serum beta 2-microglobulin and creatinine clearance values were not different between the two groups but urinary excretion of beta 2-microglobulin was three times higher in the hypertensive patients. This difference disappeared within seven days of delivery. These results indicate that a reversible renal tubular lesion occurs in pregnancy-induced hypertension even in the absence of detectable proteinuria.
Serum and urine beta 2-microglobulin concentrations were measured in 17 primigravidas with mild pregnancy-induced hypertension and nine normotensive control patients matched for gestational age. Serum beta 2-microglobulin and creatinine clearance values were not different between the two groups but urinary excretion of beta 2-microglobulin was three times higher in the hypertensive patients. This difference disappeared within seven days of delivery. These results indicate that a reversible renal tubular lesion occurs in pregnancy-induced hypertension even in the absence of detectable proteinuria.