Related Experiment Video
Updated: Aug 23, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
[Relation between estrogen and progesterone receptors and response to hormone therapy]
Abstract:
In mammary cancers, and more especially at the stage of generalization, the detection of estrogen receptors plays a prominent role in the choice of treatment. Recent studies indicate that nearly half of cancers containing receptors are responsive to various hormone treatments while only a minority of cancers not containing receptors are responsive to the same treatments. The present review emphasizes the benefits of a quantitative dosage of these receptors compared to their simple detection. It also evaluates the predictive value of progesterone receptors as an additional test for hormonodependence. Finally, it analyses the part played by receptors dosage in the current therapeutic strategy as well as in the development of new clinical protocols.
Related Concept Videos
Intracellular Hormone Receptors
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Dose-Response Relationship: Overview
Target Cell Response to Hormones
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.

