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[Antibiotic sensitivity of Streptococcus group B]
Abstract:
The minimal inhibitory and bactericidal concentration of 18 antibiotics for 412 isolates of group B streptococci from newborns, mothers or pregnant women were determined. 3.2% of these strains were less susceptible to penicillin G, 1% failed to be inhibited by erythromycin and 1% by chloramphenicol. Antibiotic-killing kinetics was studied with beta-lactams, aminoglycosides, and in combination for 20 isolates. Killing was accelerated by the combination. For these reasons, at least at the beginning of the treatment, the association of ampicillin and an aminoglycoside can be recommended.
Insights
Group B Streptococcus antibiotic susceptibility was tested. Combining ampicillin with an aminoglycoside antibiotic showed accelerated killing of bacteria, suggesting this combination for initial treatment.
Area of Science:
- Microbiology
- Pharmacology
Context:
- Group B Streptococcus (GBS) is a significant cause of neonatal infections.
- Antibiotic resistance in GBS can complicate treatment strategies.
Purpose:
- To determine the minimal inhibitory and bactericidal concentrations of 18 antibiotics against 412 GBS isolates.
- To investigate the killing kinetics of selected antibiotics and their combinations.
Summary:
- 3.2% of GBS isolates showed reduced susceptibility to penicillin G, with 1% resistant to erythromycin and 1% to chloramphenicol.
- Antibiotic-killing kinetics revealed that combining beta-lactams (like ampicillin) with aminoglycosides accelerated bacterial killing.
- The combination of ampicillin and an aminoglycoside is recommended for initial GBS treatment.
Impact:
- Provides crucial data on GBS antibiotic resistance patterns.
- Informs clinical guidelines for effective GBS infection management.
- Highlights the potential benefit of combination antibiotic therapy.