Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of tinnitus.

A R Møller

    The Annals of Otology, Rhinology, and Laryngology
    |January 1, 1984
    PubMed
    Summary

    Certain tinnitus may stem from abnormal neural activity in auditory nerve fibers. This "crosstalk" creates phantom sound patterns, potentially explaining tinnitus perception without external auditory stimuli.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acute high-intensity sound exposure alters responses of place cells in hippocampus.

    Hearing research·2009
    Same author

    Tinnitus and pain.

    Progress in brain research·2007
    Same author

    Is there a place for microvascular decompression?

    Acta neurochirurgica·2005
    Same author

    Neurophysiologic basis for cochlear and auditory brainstem implants.

    American journal of audiology·2002
    Same author

    Symptoms and signs caused by neural plasticity.

    Neurological research·2001
    Same author

    Similarities between severe tinnitus and chronic pain.

    Journal of the American Academy of Audiology·2001

    Area of Science:

    • Auditory Neurophysiology
    • Tinnitus Research
    • Neural Coding

    Background:

    • Neural coding of sound's temporal patterns is crucial for complex sound analysis.
    • Ephaptic transmission (nerve fiber "crosstalk") can occur following nerve damage.
    • This crosstalk may facilitate abnormal phase-locking in auditory nerve fibers.

    Purpose of the Study:

    • To propose a hypothesis linking specific tinnitus forms to abnormal neural activity.
    • To explore the role of ephaptic transmission in auditory nerve fiber function.
    • To explain the generation of phantom auditory percepts.

    Main Methods:

    • Hypothesis formulation based on existing auditory neurophysiology data.
    • Review of studies on neural coding and ephaptic transmission.
    • Theoretical modeling of neural activity patterns.

    Main Results:

    • Hypothesized that abnormal phase-locking in auditory nerve fibers could cause tinnitus.
    • Proposed that nerve fiber crosstalk generates spontaneous neural activity.
    • This activity mimics neural patterns of actual sounds, creating phantom perceptions.

    Conclusions:

    • Abnormal neural phase-locking in auditory nerve fibers is a plausible mechanism for certain tinnitus.
    • Ephaptic transmission offers a potential pathway for this abnormal neural synchrony.
    • Further research is needed to validate this hypothesis and explore therapeutic targets.

    Related Experiment Videos