Effect of prostaglandins on chloropromazine induced catalepsy in mice

The effect of prostaglandins (PGs) F1 alpha, F2 alpha, E2, D2, A1, B1 and I2 administered intracerebroventricularly (i.c.v.) in mice in a dose of 1 microgram on catalepsy induced by chloropromazine (2.5 mg/kg i.p.) was examined. It was demonstrated that only PGF2 alpha reduced significantly the chloropromazine induced catalepsy, while PGI2 intensified it. The other examined PGs were without any effect on chlorpromazine catalepsy. The results show the modifying role of some PGs on chloropromazine effects on central dopaminergic receptors in mice.