Related Experiment Videos
Sequential changes in NK and ADCC effector cell function after organ transplantation in man.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1983
Summary
Natural killer (NK) cell activity in kidney transplant patients correlates more with rejection episodes than antibody-dependent cellular cytotoxicity (ADCC). Increased NK activity may indicate non-clonally activated T-cells during rejection.
Area of Science:
- Immunology
- Transplantation immunology
Background:
- Kidney transplantation requires immunosuppression to prevent rejection.
- Cellular cytotoxicity assays, including antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell activity, are used to monitor immune status.
- The role of NK cells and ADCC in kidney transplant rejection is not fully understood.
Purpose of the Study:
- To sequentially measure ADCC and NK cell cytotoxicity in kidney transplant patients.
- To investigate the correlation between these cytotoxic activities and rejection episodes.
- To explore the potential origin of increased NK activity during rejection.
Main Methods:
- Sequential measurement of ADCC and NK cell cytotoxicity in ten kidney transplant patients.
- Patients were on conventional immunosuppression.
- Correlation analysis between cytotoxic activities and rejection episodes.
Main Results:
- NK cell cytotoxicity showed a closer correlation with rejection episodes compared to ADCC.
- Increased NK activity was often associated with decreased ADCC activity.
- A rise in NK activity during rejection episodes was observed.
Conclusions:
- The findings suggest that NK cell activity, rather than ADCC, is a better indicator of rejection in kidney transplant patients.
- The observed increase in NK activity during rejection may be linked to the emergence of non-clonally activated T-cells in peripheral blood.
- Further research is needed to elucidate the precise mechanisms and implications of these findings.