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Giant lymph node hyperplasia with unusual clinicopathologic features.

W C Chan, H Hargreaves, J Keller

|May 15, 1984

Summary

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Giant lymph node hyperplasia (GLNH) can present with rare features, including association with amyloidosis and nephrotic syndrome, or developing after Hodgkin's disease treatment. Immunohistochemistry is crucial for understanding these unusual plasma cell variant cases.

Area of Science:

Immunopathology
Oncology
Nephrology

Background:

Giant lymph node hyperplasia (GLNH) is a rare, benign lymphoproliferative disorder.
This study investigates two unique cases of GLNH exhibiting atypical clinical and pathological characteristics.
Immunohistochemical techniques were employed to analyze the cellular composition and immunoglobulin light chain expression in both cases.

Observation:

The first case involved mesenteric GLNH co-occurring with amyloidosis and nephrotic syndrome.
The second case presented GLNH in a patient with a history of treated Hodgkin's disease.
Both GLNH cases were identified as the plasma cell variant.

Findings:

Immunohistochemistry revealed kappa and lambda light chain expression in the plasma cells of the first case.

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The second case demonstrated lambda light chain restriction in its plasma cells.

Morphological assessment alone could not predict the monoclonality of the plasma cells.

Implications:

These findings highlight the diverse presentations of GLNH, emphasizing the need for thorough diagnostic workups.
Immunohistochemistry plays a vital role in characterizing GLNH variants and assessing potential monoclonality.
Understanding these unusual clinicopathologic features aids in differential diagnosis and patient management.