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Opiates modulate insulin action in vivo in dogs
Diabetologia
|January 1, 1984
Summary
Opiate agonists and antagonists alter how insulin affects glucose metabolism. Insulin
Area of Science:
- Endocrinology
- Pharmacology
- Metabolic Research
Background:
- Opiates are known to affect various physiological processes.
- The impact of opiates on insulin action and glucose homeostasis requires further elucidation.
Purpose of the Study:
- To investigate the in vivo influence of opiate agonists and antagonists on insulin-mediated glucose metabolism.
- To determine the effects of D-met2-pro5-enkephalinamide (DMPE) and naloxone on glucose production and utilization during hyperinsulinemia.
Main Methods:
- Utilized isotope dilution techniques with 3-3H-glucose in trained conscious dogs.
- Induced mild physiological hyperinsulinemia in the absence or presence of DMPE or naloxone infusions.
- Measured changes in glucose production and glucose utilization.
Main Results:
- Insulin-induced glucose reduction was similar across control, DMPE, and naloxone groups.
- In control dogs, insulin suppressed glucose production without altering utilization.
- In contrast, DMPE and naloxone groups showed increased glucose utilization and a failure of insulin to suppress glucose production.
Conclusions:
- Opiate agonists and antagonists significantly alter insulin's mechanism of action on glucose metabolism.
- These findings suggest that opiates interfere with the normal suppressive effect of insulin on glucose production, while enhancing glucose utilization.