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Single injection techniques in determining age-related changes in porcine renal function.
The International Journal of Applied Radiation and Isotopes
|February 1, 1984
Summary
Renal function in pigs, including glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), significantly increases up to one year of age. These kidney function parameters can be accurately measured using single injection methods.
Area of Science:
- Nephrology
- Veterinary Medicine
- Physiology
Background:
- Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) are key indicators of kidney function.
- Previous studies often utilized continuous infusion techniques for monitoring renal parameters.
Purpose of the Study:
- To determine GFR and ERPF in pigs across different age groups.
- To evaluate the efficacy of single injection procedures for monitoring renal function in pigs.
- To establish age-related reference values for porcine renal function.
Main Methods:
- GFR and ERPF were measured in 32 anesthetized female Large pigs (4-24 months old).
- Plasma disappearance curves of [99mTc]DTPA and [131I]hippuran were used to determine GFR and ERPF, respectively.
- External cardiac counting monitored clearance, validating plasma clearance data.
Main Results:
- GFR and ERPF increased significantly with age in pigs up to 12 months.
- Mean GFR reached 242.06 +/- 5.89 mL/min and mean ERPF reached 919.39 +/- 79.01 mL/min in pigs aged 12 months.
- Renal function stabilized after one year of age, with only slight increases in ERPF observed between 12-24 months.
Conclusions:
- Porcine renal function, specifically GFR and ERPF, demonstrates marked development during the first year of life.
- Single injection techniques provide accurate measurements of GFR and ERPF in pigs, comparable to continuous infusion methods.
- The study provides valuable age-specific reference data for porcine renal function.