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Aortic insufficiency in chronic renal failure.
Acta Medica Scandinavica
|January 1, 1978
Summary
A diastolic murmur in advanced renal failure patients is often functional, not organic. This murmur disappears with hemodialysis or renal transplantation, indicating a reversible condition.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Patients with advanced renal failure may present with cardiac murmurs.
- A diastolic decrescendo murmur along the left sternal border was observed in 21 patients.
Observation:
- Eight patients had confirmed organic aortic insufficiency.
- In 13 patients without organic aortic insufficiency, angiocardiography revealed aortic regurgitation in 4 and coronary artery stenosis in 2.
- Autopsies showed normal aortic ostia in deceased patients.
Findings:
- The diastolic murmur in advanced renal failure is likely functional.
- This functional murmur resolves with renal replacement therapy, including hemodialysis and renal transplantation.
Implications:
- The study suggests a non-organic cause for diastolic murmurs in renal failure patients.
- Clinical management should consider the reversibility of these murmurs with dialysis or transplantation.
- Further research into the mechanisms of functional murmurs in renal failure is warranted.