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[The physiopathological basis for hemorrheological changes in diabetes]
La Ricerca in Clinica E in Laboratorio
|January 1, 1983
Summary
Diabetes mellitus alters blood rheology due to hemostatic system changes, affecting blood viscosity and flow. These changes impact microcirculation and erythrocyte deformability.
Area of Science:
- Biomedical Engineering
- Hematology
- Endocrinology
Context:
- Blood rheology is crucial for microcirculation, influenced by blood properties and local conditions.
- Diabetes mellitus and impaired glucose tolerance are associated with platelet dysfunction and altered hemostasis.
Purpose:
- To elucidate the relationship between hemostatic system alterations and changes in blood viscosity and rheology in diabetes mellitus.
Summary:
- Diabetes mellitus is linked to platelet hypercoagulability, hyperaggregability, and reduced prostacyclin production.
- These hemostatic changes increase plasma viscosity, promote platelet aggregate formation, and decrease erythrocyte deformability.
- Consequently, blood viscosity and rheological disturbances in diabetes mellitus stem from hemostatic system dysfunctions.
Impact:
- Understanding these rheological changes provides insights into diabetes-related vascular complications.
- This knowledge can inform therapeutic strategies targeting hemostasis to improve microcirculatory function in diabetic patients.