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Glipizide: an overview.

The American Journal of Medicine

|November 30, 1983

Summary

This summary is machine-generated.

Glipizide effectively treats noninsulin-dependent diabetes mellitus by improving insulin action and glucose control. This oral hypoglycemic is well-tolerated, with rare hypoglycemia when used correctly.

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Area of Science:

Endocrinology
Pharmacology
Metabolic Diseases

Background:

Noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and impaired insulin secretion.
Effective management of NIDDM requires addressing both defective secretory dynamics and target-cell resistance to insulin.

Purpose of the Study:

To summarize clinical experience with glipizide, an oral hypoglycemic agent, for NIDDM treatment.
To highlight glipizide's unique properties and efficacy in managing blood glucose levels.

Main Methods:

Extensive clinical experience with glipizide in NIDDM patients.
Review of glipizide's effects on insulin action, secretion, and glucose metabolism.

Main Results:

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Glipizide stimulates insulin action via extrapancreatic effects, enhancing insulin-receptor binding and tissue responsiveness.

It favorably influences NIDDM pathophysiology, improving blood glucose control and potentially reducing insulin dosage when used concurrently with insulin.

Glipizide is effective, well-tolerated, and demonstrates superiority over tolbutamide in elderly patients with long-standing diabetes.

Conclusions:

Glipizide is an effective and safe oral hypoglycemic agent for managing noninsulin-dependent diabetes mellitus.
Its unique properties, including improved insulin action and glucose control, support its use in NIDDM management.
Appropriate usage minimizes the risk of hypoglycemia, making it a recommended treatment option.