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Diabetic neuropathy.

M J Brown, A K Asbury

Annals of Neurology

|January 1, 1984

Summary

Diabetic neuropathy, a complication of diabetes, arises from high blood sugar. Managing blood glucose is key for treatment until specific therapies are developed.

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Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation.

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Neurology·2008

Same author

Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review) [RETIRED]. Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation.

Neurology·2008

Area of Science:

Neurology
Endocrinology
Metabolic Disorders

Background:

Peripheral nerve disorders are significant late complications of diabetes mellitus.
Diabetic polyneuropathy results from metabolic disturbances due to chronic hyperglycemia.
Other diabetic neuropathies include symmetrical proximal motor neuropathy (diabetic amyotrophy) and mononeuropathies potentially caused by ischemia or compression.

Purpose of the Study:

To review the understanding of the biochemical basis of diabetic polyneuropathy.
To outline current treatment strategies for symptomatic diabetic neuropathy.

Main Methods:

Review of existing literature on diabetic neuropathy.
Analysis of biochemical pathways implicated in nerve damage.
Evaluation of current therapeutic approaches.

Main Results:

Significant advances have been made in elucidating the biochemical underpinnings of diabetic polyneuropathy.
Current treatment focuses on managing hyperglycemia to mitigate nerve damage.

Conclusions:

Long-term normalization of blood glucose is the primary treatment for symptomatic diabetic neuropathy.
Further research into specific therapies is warranted as understanding of the biochemical basis grows.

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