Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methacholine challenge test.

L J Fetters, J I Matthews

    Archives of Internal Medicine
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Methacholine challenge can help diagnose asthma when spirometry is inconclusive. However, a positive test result is not specific to asthma, indicating a need for stricter diagnostic criteria.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Process evaluation of the Centrally Procured School Food Program (CPSFP) in Ontario, Canada: school-level perspectives.

    Health education research·2021
    Same author

    An in situ study of the t-butyllithium initiated polymerization of butadiene in d-heptane via small angle neutron scattering and 1H-NMR.

    The Journal of chemical physics·2005
    Same author

    Cost-effective syphilis screening in military recruit applicants.

    Military medicine·1999
    Same author

    Suppression of rupture in thin, nonwetting liquid films.

    Science (New York, N.Y.)·1994
    Same author

    Complete wetting from polymer mixtures.

    Science (New York, N.Y.)·1992
    Same author

    Exercise dysfunction in patients seropositive for the human immunodeficiency virus.

    The American review of respiratory disease·1990
    Same journal

    Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

    Archives of internal medicine·2017
    Same journal

    Occult Carbon Monoxide Poisoning-Reply.

    Archives of internal medicine·2017
    Same journal

    Acquired Immune Deficiency Syndrome-Reply.

    Archives of internal medicine·2017
    Same journal

    Heparin Side Effects-Reply.

    Archives of internal medicine·2017
    Same journal

    Humanizing primary care medicine begins with stress.

    Archives of internal medicine·2017
    Same journal

    Legend omitted and number misrepresented.

    Archives of internal medicine·2013
    See all related articles

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Diagnostics

    Background:

    • Clinical asthma diagnosis can be challenging when spirometry fails to show reversible airway obstruction.
    • Methacholine challenge is a proposed diagnostic method for such cases.

    Purpose of the Study:

    • To evaluate the utility of methacholine challenge in diagnosing suspected asthma.
    • To assess the specificity and sensitivity of methacholine challenge criteria.

    Main Methods:

    • Administered methacholine challenge to 14 patients with suspected asthma and 5 healthy controls.
    • Assessed airway obstruction using forced expiratory volume in 1 second (FEV1) reduction.
    • Applied American Thoracic Society (ATS) criteria for positive bronchoprovocation.

    Main Results:

    Related Experiment Videos

    • A significant FEV1 reduction (≥20%) occurred in 8 individuals (6 patients, 2 controls) at 100 inhalation units (IUs).
    • Seven individuals (6 patients, 1 control) met ATS criteria for a positive test.
    • Four individuals (2 patients, 2 controls) showed no methacholine sensitivity.

    Conclusions:

    • While a negative methacholine challenge can exclude asthma, a positive result is not asthma-specific.
    • Stricter criteria, like a 20% FEV1 reduction at 20 IUs, may improve asthma diagnostic specificity but reduce sensitivity.