Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormonal dysregulations in severe burns.

D Balogh, R Moncayo, M Bauer

    Burns, Including Thermal Injury
    |April 1, 1984
    PubMed
    Summary

    Deep burn injuries significantly decrease testosterone levels and alter pituitary-gonadal hormone responses (FSH, LH). Pancreatic insulin production adequately manages hyperglycemia post-burn.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Guidelines for safety and quality in anaesthesia practice in the European Union.

    European journal of anaesthesiology·2007
    Same author

    [Breast cancer during pregnancy -- a challenge for the anaesthesiologist?].

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2004
    Same author

    Pulmonary arteriovenous fistula detected with transesophageal contrast echocardiography.

    Journal of cardiothoracic and vascular anesthesia·2001
    Same author

    Exogenous neopterin causes cardiac contractile dysfunction in the isolated perfused rat heart.

    Journal of molecular and cellular cardiology·2000
    Same author

    National publication output in medical research.

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·1999
    Same author

    Differential gene expression of CINC, NOS II, and ICAM-1 in endotoxemic liver cells by rG-CSF.

    Langenbeck's archives of surgery·1999

    Area of Science:

    • Endocrinology
    • Burn Medicine
    • Physiology

    Background:

    • Severe burns (30-70% body surface) cause significant physiological stress.
    • Hormonal imbalances are common following major trauma, impacting recovery.

    Purpose of the Study:

    • To investigate pituitary, thyroid, and gonadal hormone levels in patients with deep burns.
    • To assess hormonal responses to combined arginine, TRH-LHRH stimulation tests post-burn.

    Main Methods:

    • Measured pituitary (FSH, LH, HGH), thyroid, and gonadal (testosterone) hormones in 10 burn patients.
    • Utilized a combined arginine, thyrotropin-releasing hormone (TRH), and luteinizing hormone-releasing hormone (LHRH) stimulation test.
    • Monitored hormone levels during the first 20 days post-injury.

    Main Results:

    • Significantly decreased testosterone concentrations observed throughout the study period.
    • Initial prompt FSH and LH response to LHRH stimulation (0-10 days), followed by lower basal levels and delayed response (10-20 days).
    • Normal pancreatic insulin production effectively managed hyperglycemia despite high glucose and insulin levels during fluid therapy; HGH levels remained comparable to controls.

    Conclusions:

    • Deep burns profoundly affect the pituitary-gonadal axis, particularly testosterone levels.
    • Hormonal responses to stimulation change dynamically in the early post-burn period.
    • Endogenous insulin response is sufficient to prevent severe hyperglycemia in burn patients receiving glucose infusions.

    Related Experiment Videos