On the mechanism of myocardial sensitization to catecholamines by hydrocarbon anesthetics

During the past decade, considerable progress has been made in our understanding of the mechanism underlying sensitization of the heart to the arrhythmogenic action of the catecholamines by hydrocarbon anesthetics. This review includes the following: a brief discussion on the concepts of the mechanics of induction of cardiac arrhythmia; recent studies on sensitization with special reference to the primary locus of this action and the principal mechanisms involved; and the contribution made by microelectrode studies on various types of cardiac tissue and the importance of cardiodynamic effects. In addition, atrioventricular conduction studies using bundle of His preparations are described. Drug interaction between anesthetic agents, muscle relaxants, and other drugs are discussed. Suggestions for future research and a section of summary and conclusions are included.