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Related Experiment Videos

Pseudomonas maltophilia pseudosepticemia.

J D Semel, G M Trenholme, A A Harris

    The American Journal of Medicine
    |March 1, 1978
    PubMed
    Summary

    Contaminated blood collection tubes can cause false Pseudomonas maltophilia infections. This study identified black-top tubes as a source, leading to pseudosepticemia and potential true infections.

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    Area of Science:

    • Clinical Microbiology
    • Infectious Diseases
    • Medical Device Contamination

    Background:

    • Pseudomonas maltophilia (now often referred to as Stenotrophomonas maltophilia) is an opportunistic pathogen.
    • False-positive blood cultures can lead to inappropriate antibiotic use and diagnostic confusion.

    Purpose of the Study:

    • To investigate the source of recurrent false-positive blood cultures for Pseudomonas maltophilia.
    • To determine if evacuated collection tubes were responsible for contamination.

    Main Methods:

    • Retrospective review of 25 cases with positive blood cultures for Pseudomonas maltophilia.
    • Analysis of blood draw procedures and collection tube types.
    • In vitro mock trials to simulate contamination pathways.

    Main Results:

    • 25 hospitalized adult patients had blood cultures positive for Pseudomonas maltophilia over 17 months.
    • Contamination was traced to black-top evacuated collection tubes used for coagulation studies.
    • Cultures of these tubes showed high levels of Pseudomonas maltophilia; mock trials confirmed false-positive blood cultures.

    Conclusions:

    • Contaminated evacuated collection tubes are a significant source of pseudosepticemia.
    • These tubes can lead to diagnostic errors and potentially true infections, such as prosthetic valve superinfection.
    • Strict quality control of blood collection devices is crucial to prevent misdiagnosis and patient harm.

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