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Related Experiment Videos

Chorea and polycythaemia.

G W Bruyn, G Padberg

    European Neurology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Polycythemia can cause chorea, a movement disorder, predominantly in women over 50. This condition, polycythemic chorea, is linked to blood viscosity and brain metabolism, not caudate nucleus infarcts.

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    Area of Science:

    • Neurology
    • Hematology
    • Movement Disorders

    Background:

    • Chorea is a neurological disorder characterized by involuntary, irregular, dance-like movements.
    • Polycythemia is a condition where the body makes too many red blood cells, increasing blood viscosity.

    Purpose of the Study:

    • To analyze the characteristics of chorea as a symptom of polycythemia.
    • To investigate the demographic, clinical, and potential pathophysiological aspects of polycythemic chorea.

    Main Methods:

    • Retrospective analysis of 35 cases of chorea associated with polycythemia.
    • Clinical observation and assessment of patient demographics, symptom presentation, and treatment responses.

    Main Results:

    • Polycythemic chorea predominantly affects females over 50 (4:1 female:male ratio).

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  • Symptoms include generalized chorea, faciolingual and brachial muscle involvement, and hypotonia.
  • Treatment response varies, with haloperidol, venesection, or 32P-therapy showing efficacy, though spontaneous remission or recurrence can occur.

    • Conclusions:

    • Polycythemia should be considered in elderly patients presenting with chorea, especially 'senile' chorea.
    • The underlying mechanism is hypothesized to be a neostriatal hyperviscosity syndrome affecting brain metabolism.
    • Further research is needed to confirm the role of dopamine and platelets in polycythemic chorea.