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Related Experiment Videos

The perforating disorders.

J W Patterson

    Journal of the American Academy of Dermatology
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This review explores skin diseases with epidermal perforation, a process called transepithelial elimination (TEE). It discusses four key perforating disorders and suggests a new classification due to overlapping features.

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    Area of Science:

    • Dermatology
    • Histopathology

    Background:

    • Epidermal perforation is a histologic feature in various skin diseases.
    • Transepithelial elimination (TEE) is a mechanism for removing abnormal substances from the skin.

    Purpose of the Study:

    • To review diseases exhibiting epidermal perforation.
    • To discuss four essential perforating disorders: elastosis perforans serpiginosa (EPS), reactive perforating collagenosis (RPC), perforating folliculitis (PF), and Kyrle's disease (KD).
    • To propose a working classification for perforating disorders.

    Main Methods:

    • Literature review of epidermal perforation and transepithelial elimination.
    • Analysis of clinical and histologic features of four key perforating disorders.
    • Inclusion of recent literature on perforating diseases associated with chronic renal failure.

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    Main Results:

    • Many diseases showing epidermal perforation are examples of TEE.
    • Significant clinical and histologic overlap exists among PF, KD, and adult perforating collagenosis.
    • A need for a revised classification of perforating disorders is indicated.

    Conclusions:

    • Epidermal perforation is a significant histologic finding in dermatology.
    • Transepithelial elimination (TEE) is a key mechanism in these conditions.
    • A revised classification is proposed to better delineate overlapping perforating disorders.