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Glucocorticoid receptors: from development to aging. A review
Mechanisms of Ageing and Development
|February 1, 1984
Summary
Glucocorticoid receptor changes with age are reviewed, focusing on number, affinity, and properties. Understanding these age-related alterations is crucial for future research and therapeutic strategies.
Area of Science:
- Endocrinology
- Gerontology
- Molecular Biology
Background:
- Glucocorticoid responses vary across the lifespan.
- Age-related changes in tissues suggest potential alterations in glucocorticoid receptors.
Purpose of the Study:
- To review age-dependent changes in glucocorticoid receptors.
- To discuss mechanisms and future research directions for these changes.
Main Methods:
- Literature review of studies on glucocorticoid receptor ontogeny and aging.
- Summary of research on receptor number, affinity, and physicochemical properties.
Main Results:
- Glucocorticoid receptors undergo significant changes during development and aging.
- Alterations in receptor number and affinity are observed with age.
Conclusions:
- Age-related changes in glucocorticoid receptors are a significant area of research.
- Further investigation into mechanisms and therapeutic interventions is warranted.