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Related Experiment Videos

Trazodone and mianserin in general practice.

G Beaumont, M Gringras, S I Ankier

    Psychopathology
    |January 1, 1984
    PubMed
    Summary

    Trazodone and mianserin equally reduced depression and anxiety symptoms in general practice patients. However, trazodone showed significantly fewer side effects, making it a more acceptable treatment option.

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    Area of Science:

    • Psychiatry
    • Clinical Pharmacology

    Background:

    • Depression and anxiety are common conditions in general practice.
    • Pharmacological interventions are a cornerstone of treatment.
    • Comparing the efficacy and tolerability of different antidepressant medications is crucial for optimizing patient care.

    Purpose of the Study:

    • To compare the efficacy and tolerability of trazodone and mianserin in treating depression in general practice patients.
    • To assess the impact of these medications on depression and anxiety symptoms.
    • To evaluate patient-reported side effects and withdrawal rates.

    Main Methods:

    • A double-blind, noncrossover study involving 125 general practice patients with depression (minimum Hamilton Depression Rating Scale score of 14).
    • Patients were randomized to receive either trazodone (100-200 mg nocte) or mianserin (60-120 mg nocte) for 6 weeks.
    • Efficacy was assessed using the Hamilton Depression Rating Scale (HDRS) and anxiety symptoms using the Zung Self-Rating Anxiety Scale.

    Main Results:

    • Both trazodone and mianserin significantly reduced depression and anxiety symptoms, with comparable efficacy (mean HDRS decrease from ~21 to ~6 for both).
    • Withdrawal rates due to side effects were significantly higher in the mianserin group (22/31) compared to the trazodone group (5/12) (p < 0.001).
    • Daytime drowsiness was a frequent reason for mianserin withdrawal.

    Conclusions:

    • Trazodone and mianserin demonstrate similar effectiveness in treating depression and anxiety.
    • Trazodone is better tolerated than mianserin, with significantly fewer withdrawals due to side effects.
    • Trazodone may be a more acceptable treatment option for general practice patients with depression, considering its improved side effect profile.

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