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Cystic kidneys: an enigma evolves.

K D Gardner, A P Evan

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |May 1, 1984
    PubMed
    Summary
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    Acquired renal cell disease (RCD) and acquired polycystic kidney disease (APKD) may be premalignant lesions in patients undergoing hemodialysis. Further research is urgently needed to confirm this possibility and understand RCD complications.

    Area of Science:

    • Nephrology
    • Oncology
    • Renal Cell Disease (RCD) research

    Background:

    • Over the past 15 years, significant advancements have been made in the field of Renal Cell Disease (RCD).
    • There is a growing recognition and understanding of acquired RCD and its associated complications.

    Purpose of the Study:

    • To review published data regarding acquired Renal Cell Disease (RCD) and Acquired Polycystic Kidney Disease (APKD).
    • To evaluate the potential of APKD and RCD acquired during hemodialysis as premalignant lesions.

    Main Methods:

    • Review of existing published data on acquired RCD and APKD.
    • Analysis of data to support or refute the hypothesis of premalignant potential.

    Main Results:

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  • Published data suggest a possibility that APKD and RCD acquired during hemodialysis may represent premalignant lesions.
  • Current data are insufficient to definitively confirm or deny this possibility.

    • Conclusions:

    • Acquired RCD and APKD in hemodialysis patients warrant further investigation as potential premalignant conditions.
    • The urgent collection of additional data is necessary to confirm the premalignant nature of these lesions and guide future research in RCD.