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Alkaline reflux gastritis and esophagitis
Annual Review of Medicine
|January 1, 1984
Summary
Alkaline reflux gastritis and esophagitis are caused by duodenal contents injuring the stomach and esophagus. Surgical therapy to divert duodenal contents offers benefit for patients with alkaline reflux.
Area of Science:
- Gastroenterology
- Pathophysiology
- Surgical Treatment
Background:
- Alkaline reflux gastritis and esophagitis stem from duodenal contents causing mucosal injury.
- These conditions can occur after gastric surgery, cholecystectomy, or sphincteroplasty, and rarely in non-operated individuals.
- Symptoms include epigastric pain, bilious vomiting, weight loss, and anemia.
Purpose of the Study:
- To review the pathophysiology, diagnosis, and treatment of alkaline reflux gastritis and esophagitis.
Main Methods:
- Review of existing literature on alkaline reflux gastritis and esophagitis.
- Discussion of diagnostic features and emerging diagnostic techniques.
- Evaluation of medical and surgical treatment options.
Main Results:
- Diagnostic features include chronic epigastric pain, bilious vomiting, weight loss, anemia, and intragastric bile.
- Pathophysiology involves excess enterogastric reflux and bile-induced mucosal damage.
- Medical therapies have shown limited benefit, while surgical diversion of duodenal contents is often effective.
Conclusions:
- Alkaline reflux gastritis and esophagitis are significant conditions requiring appropriate management.
- Surgical intervention is a beneficial option for selected patients.
- Further evaluation of treatments like prostaglandins and sucralfate is ongoing.
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