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Related Experiment Videos

Human insulin.

R G Larkins

    Australian and New Zealand Journal of Medicine
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Two methods for producing human insulin, biosynthetic and semisynthetic, are commercially available. While safe and effective, they offer limited advantages over animal insulin for routine diabetes management.

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    Area of Science:

    • Endocrinology
    • Biotechnology
    • Pharmacology

    Background:

    • Two commercial methods for human insulin synthesis exist: biosynthetic (bacterial) and semisynthetic (pork insulin conversion).
    • Both human insulin forms demonstrate safety, efficacy, and pharmacokinetic profiles comparable to purified pork insulin.

    Purpose of the Study:

    • To evaluate the safety, efficacy, and immunogenicity of human insulin compared to purified animal insulin.
    • To assess the clinical significance of antibody formation with human insulin use.
    • To explore the advantages of human insulin in specific patient populations.

    Main Methods:

    • Review of studies on biosynthetic and semisynthetic human insulin production and clinical use.
    • Comparison of pharmacokinetic and efficacy data between human and animal insulins.

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  • Analysis of immunogenicity data, including antibody formation and clinical implications.

    • Main Results:

    • Human insulin, both biosynthetic and semisynthetic, is safe and effective, with similar pharmacokinetics to purified pork insulin.
    • Subcutaneous human insulin can elicit antibody formation, though potentially less than purified pork or beef insulins.
    • Human insulin shows advantages in rare cases of pork insulin allergy or antibody-mediated insulin resistance.

    Conclusions:

    • Biosynthetic human insulin ensures a stable global supply and may become more cost-effective than animal insulin extraction.
    • Current evidence does not support routine use of human insulin over purified animal insulin for diabetes management.
    • Human insulin offers specific benefits for patients with allergies or resistance to animal-derived insulins.