[Acid hydrolase activity of the blood in immunodepression]

Immunosuppressants reduce the activity of acid RNase and acid phosphatase in the blood serum of mice and patients with kidney allografts. In reversible graft rejection crises, the activity of both enzymes ascends in the period preceding the crisis or at its height. However, following intensive immunosuppressive therapy it drops again. In irreversible crises, the activity of acid hydrolases goes on ascending in spite of immunosuppression intensification. The time course of the activity of these enzymes correlates with changes in "active" and "total" T-rosette-forming cells.