[Hemodynamic changes in pulmonary embolism induced by bone marrow in the dog]

Embolisation with allogenic bone marrow administered into the femoral vein was performed in 12 dogs, anaesthetized and heparinized. The ECG and ventricular, aortic and pulmonary artery pressures were recorded by catheterization. From these the following parameters were calculated: cardiac output (CO), by thermodilution; modified cardiac index (CO/M); systolic cardiac index (CO/M/F); work performance of right and left ventricle (Wr, W1); ejection indices of right and left ventricle (Wr/M/F, W1/M/F); first derivative of left ventricular pressure (dp/dt) max and the total pulmonary (TPR) and systemic (TSR) resistance. All parameters were studied also in 12 control ( nonembolized ) dogs. The most significant haemodynamic changes found in the embolized group were as follows: 1) a lowering of the end-diastolic pressure in the left ventricle, of the W1 and W1/M/F, of the Wr with a slight augmentation in the 15th min after embolisation, Wr/M/F and CO/M/F; 2) a rise in heart rate, an augmentation of TPR during the first minutes of the experiment, and of TSR at the end of the experiment.