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C-peptide measurement: methods and clinical utility.

A M Bonser, P Garcia-Webb

Critical Reviews in Clinical Laboratory Sciences

|January 1, 1984

Summary

Circulating C-peptide levels accurately measure pancreatic beta-cell function. C-peptide measurements are superior to insulin tests for assessing secretory activity in various diabetic conditions.

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Area of Science:

Biochemistry
Endocrinology
Metabolic Research

Background:

Proinsulin is the precursor to insulin, comprising insulin and a connecting C-peptide.
Pancreatic beta-cells secrete insulin and C-peptide in equimolar amounts.
Circulating C-peptide levels reflect beta-cell secretory activity.

Purpose of the Study:

To review methods for determining C-peptide levels in body fluids.
To discuss the applications of C-peptide measurements.
To evaluate C-peptide's role in understanding factors influencing insulin secretion.

Main Methods:

Review of existing literature on C-peptide determination methods.
Analysis of C-peptide measurement applications in clinical investigations.
Evaluation of correlations between C-peptide levels and physiological/metabolic parameters.

Main Results:

C-peptide measurements offer advantages over insulin assays due to lack of hepatic extraction and slower clearance.
C-peptide is valuable for investigating hypoglycemia.
C-peptide assessment aids in evaluating insulin secretory function in diabetics.

Conclusions:

C-peptide measurement is a reliable indicator of pancreatic beta-cell secretory function.
C-peptide assays are clinically useful for managing diabetes and investigating metabolic disorders.
Further understanding of C-peptide's relationship with age, sex, obesity, lipids, and glucose is provided.

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