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Serratia marcescens meningitis associated with a contaminated benzalkonium chloride solution
Abstract:
Serratia marcescens is recognized as an important and potentially hazardous nosocomial pathogen. The organism has been implicated here as the first reported case of S. marcescens meningitis associated with skin disinfection. A quaternary ammonium compound ( QAC --Benzalkonium Chloride), was used to sterilize the skin prior to injection in a physician's office. Epidemiological studies were initiated. Six spray bottles containing disinfectant, the opened stock bottle of QAC , and an unopened bottle of disinfectant were all cultured. S. marcescens was noted growing in the spray bottles as well as in the opened stock bottle. Antibiograms of the patient and epidemiological isolates are essentially the same. It is our contention as well as that of the Centers for Disease Control that an appropriate skin disinfectant such as Tincture of Chlorhexidine, Iodophors , or Tincture of Iodine should be used, and that physicians performing surgical techniques in the office be aware of the potential hazard of contamination. The consequences of nosocomial infection with resistant organisms warrant every precaution by health care professionals.
Insights
Serratia marcescens meningitis was linked to skin disinfection with a quaternary ammonium compound (QAC). Healthcare professionals should use alternative disinfectants to prevent nosocomial infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Serratia marcescens is a significant nosocomial pathogen.
- Nosocomial infections pose a serious threat in healthcare settings.
Observation:
- A case of S. marcescens meningitis was associated with skin disinfection.
- The disinfectant used was a quaternary ammonium compound (Benzalkonium Chloride).
- S. marcescens was isolated from the disinfectant spray bottles and opened stock bottle.
Findings:
- Epidemiological studies confirmed the link between the disinfectant and the infection.
- Antimicrobial susceptibility patterns of the patient and environmental isolates were identical.
- The quaternary ammonium compound disinfectant was contaminated with S. marcescens.
Implications:
- Alternative skin disinfectants like Chlorhexidine, Iodophors, or Tincture of Iodine are recommended.
- Physicians must be aware of potential contamination hazards with office-based procedures.
- Strict adherence to infection control protocols is crucial to prevent resistant organism spread.