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Absorbable versus nonabsorbable suture for microneurorrhaphy.

R B Cham, C A Peimer, C S Howard

    The Journal of Hand Surgery
    |May 1, 1984
    PubMed
    Summary
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    Comparing absorbable and nonabsorbable sutures for sciatic nerve repair in rats revealed no significant differences in axonal regeneration. However, absorbable sutures led to less chronic inflammation post-repair.

    Area of Science:

    • Neurosurgery
    • Regenerative Medicine
    • Biomaterials Science

    Background:

    • Microsuture selection is critical for successful nerve repair outcomes.
    • Understanding the inflammatory response to different suture materials is essential for optimizing surgical techniques.

    Purpose of the Study:

    • To compare the efficacy of absorbable versus nonabsorbable microsutures in epineural repair of transected sciatic nerves.
    • To evaluate the impact of suture type on clinical, electrodiagnostic, and histological parameters of axonal regeneration.

    Main Methods:

    • Epineural microneurorrhaphy was performed on 150 Sprague-Dawley rats using 10/0 monofilament absorbable (Vicryl, Dexon) and nonabsorbable (Dermalon, Ethilon, Prolene) sutures.
    • Animals were monitored clinically and electrodiagnostically at 6, 12, and 20 weeks post-repair.

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  • Histological examination assessed inflammation and nerve regeneration.

    • Main Results:

    • No significant differences in clinical, electrodiagnostic, or histological outcomes for axonal regeneration were observed between suture groups.
    • Both suture types induced acute localized inflammation.
    • Absorbable sutures resolved inflammation post-dissolution, while nonabsorbable sutures resulted in persistent local granulomas.

    Conclusions:

    • Monofilament absorbable sutures demonstrate comparable efficacy to nonabsorbable sutures for sciatic nerve repair in terms of axonal regeneration.
    • Absorbable sutures may offer an advantage by minimizing chronic inflammation associated with nonabsorbable suture materials.