[Basic and clinical studies on ceftazidime in the field of obstetrics and gynecology]

Basic and clinical studies on ceftazidime ( CAZ ) were carried out in the field of obstetrics and gynecology. The following results were obtained. The CAZ levels in the pelvic dead space exudate and serum were measured with passage of time in patients undergoing radical hysterectomy with pelvic lymphadenectomy for uterine cervical cancer after intravenous drip infusion of 1 g for 30 minutes. The serum level attained the peak of 87.0 micrograms/ml immediately after completion of the drip infusion and rapidly decreased thereafter. On the other hand, the pelvic dead space exudate level reached the peak of 27.9 micrograms/ml at 1 hour after completion of the drip infusion and gradually decreased thereafter, keeping higher levels than the serum levels. A total of 10 cases comprising 2 of adnexitis, 1 of pelvioperitonitis , 2 of pyometra and 5 of BARTHOLIN's abscess was treated with CAZ intravenous injection at a dose of 1 g twice daily for 5 approximately 6 days. The clinical efficacy was excellent in 1 case and good in 9 cases. Neither adverse reactions nor abnormal laboratory findings were observed in any of the cases.