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Related Experiment Videos

[Circulating immune complexes before and after kidney allotransplantation].

G Keusch, H M Vonwiller, A von Felten

    Klinische Wochenschrift
    |April 16, 1984
    PubMed
    Summary

    Circulating immune complexes (CIC) are common before kidney transplants and correlate with graft number and hepatitis. Post-transplant CIC levels predict shorter graft survival, indicating their role in transplant outcomes.

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    Is heparin therapy necessary in CAPD peritonitis?

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·1997

    Area of Science:

    • Nephrology
    • Immunology
    • Transplantation Science

    Context:

    • Circulating immune complexes (CIC) are implicated in various autoimmune and post-transplant complications.
    • Assessing CIC levels pre- and post-renal transplantation is crucial for understanding graft outcomes.

    Purpose:

    • To analyze the role of circulating immune complexes (CIC) in renal transplant recipients.
    • To determine the correlation of pre-transplant CIC levels with patient and graft characteristics.
    • To evaluate the association of post-transplant CIC levels with graft survival.

    Summary:

    • A prospective study analyzed CIC in 141 renal transplant patients using the Raji cell assay.
    • Pre-transplant CIC were detected in 73.8% of patients and correlated with graft number and chronic active hepatitis.

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  • Post-transplant, elevated CIC levels were observed in 41% of patients, with significantly higher levels in those experiencing graft loss within 11 months.

    • Impact:

    • Elevated post-transplant CIC levels are significantly associated with reduced graft survival.
    • CIC measurement may serve as a biomarker for predicting renal transplant outcomes.
    • Further research into the mechanisms of CIC in renal allograft rejection is warranted.