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Related Experiment Videos

B-lymphocyte alloantigens associated with multiple sclerosis.

D A Compston, J R Batchelor, W I McDonald

    Lancet (London, England)
    |December 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Researchers identified B-lymphocyte alloantigens, finding a strong association between BT 101 antigen and multiple sclerosis (M.S.). This discovery may aid in identifying individuals at higher risk for M.S.

    Area of Science:

    • Immunogenetics
    • Neurology

    Background:

    • B-lymphocyte alloantigens are cell surface markers.
    • Previous studies have identified several B-cell antigens.

    Purpose of the Study:

    • To investigate the association between B-lymphocyte alloantigens and multiple sclerosis (M.S.).
    • To determine if specific B-cell antigens increase susceptibility to M.S.

    Main Methods:

    • Lymphocytotoxic antisera were used to identify B-lymphocyte alloantigens.
    • The frequency of these antigens was compared between M.S. patients and healthy controls.

    Main Results:

    • The B-cell antigen BT 101 was found in 83% of M.S. patients versus 33% of controls, a 9.8-fold increased risk.
    • Two other B-cell alloantigens and HLA-B7 also showed significant positive associations with M.S.

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    Conclusions:

    • The BT 101 antigen is strongly associated with multiple sclerosis.
    • This association may offer insights into M.S. pathogenesis and facilitate early identification of at-risk individuals.