Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibronectin: multiple interactions assigned to structural domains.

T Vartio

    Medical Biology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Collagen-Binding S-Layer Protein in Lactobacillus crispatus.

    Applied and environmental microbiology·1995
    Same author

    Type IV collagenases in human amniotic fluids and amnion epithelial cells.

    Biochimica et biophysica acta·1994
    Same author

    Increased expression of the matrix metalloproteinase 2 in differentiating Tera 2 human embryonal carcinoma cells.

    International journal of cancer·1994
    Same author

    Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator.

    Experimental cell research·1992
    Same author

    Adhesion protein YadA of Yersinia species mediates binding of bacteria to fibronectin.

    Infection and immunity·1992
    Same author

    Disulfide-bonded dimerization of fibronectin in vitro.

    European journal of biochemistry·1991
    Same journal

    Neuroanatomy of morphine-modulating peptides.

    Medical biology·1987
    Same journal

    Serum prolactin levels after buspirone in man.

    Medical biology·1987
    Same journal

    Aluminum deposition in the central nervous system. Preferential accumulation in the hippocampus in weanling rats.

    Medical biology·1987
    Same journal

    Localisation of gastric histamine: immunocytochemical observations.

    Medical biology·1987
    Same journal

    Time relationships and reversal by two indoleamines of the pinealectomy-inhibited thyrotropin secretion in male rats.

    Medical biology·1987
    Same journal

    Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.

    Medical biology·1987
    See all related articles

    Fibronectin exhibits diverse molecular interactions and widespread distribution. Its functions are linked to specific domains, and its fragments retain biological activity after degradation.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Background:

    • Fibronectin is a crucial extracellular matrix protein with extensive in vivo distribution.
    • Its structure is characterized by unique, internally homologous sequences.
    • Fibronectin participates in a wide array of molecular and biological interactions.

    Purpose of the Study:

    • To elucidate the structure-function relationships of fibronectin.
    • To understand the biological significance of fibronectin's interactive domains.
    • To investigate the role of fibronectin fragments in biological processes.

    Main Methods:

    • Structural analysis of fibronectin.
    • Biochemical assays to study protein interactions.
    • Proteolytic degradation studies.

    Related Experiment Videos

    Main Results:

    • Specific interactive domains within fibronectin dictate its functions.
    • Internal homology within fibronectin's primary structure.
    • Proteolytic fragments of fibronectin retain and exhibit unique biological effects.

    Conclusions:

    • Fibronectin's diverse functions are attributed to distinct molecular domains.
    • Fibronectin fragments possess independent biological activities.
    • Understanding fibronectin structure is key to its biological roles.