[Keratoacanthoma centrifugum marginatum]

The authors describe an observation of multiple keratoacanthomas appearing within 3 years, mainly located on the right forearm. Clear confluence and centrifugal extension, due to progressive appearance of surrounding lesions forming a 12 X 10 cm. ulcerated surface characterized this case. The topical application of 5-FU was effective, nevertheless further surrounding lesions have made their appearance. The clinico-pathological features and evolution are those of keratoacanthoma centrifugum marginatum , a rare type of multiple and localized keratoacanthoma.