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[Keratoacanthoma centrifugum marginatum].

A Poiares Baptista, A Vasconcelos, J D Freitas

    Medicina Cutanea Ibero-Latino-Americana
    |January 1, 1984
    PubMed
    Summary
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    This case study details a rare form of multiple keratoacanthoma, specifically keratoacanthoma centrifugum marginatum, presenting on the forearm. Topical 5-fluorouracil showed some effectiveness, but new lesions continued to emerge.

    Area of Science:

    • Dermatology
    • Oncology

    Background:

    • Keratoacanthomas are common skin tumors, typically self-limiting.
    • Keratoacanthoma centrifugum marginatum is a rare variant characterized by multiple, localized lesions with centrifugal growth.

    Observation:

    • A case of multiple keratoacanthomas developed over 3 years, primarily on the right forearm.
    • Lesions coalesced and extended centrifugally, forming a large, ulcerated surface (12 x 10 cm).

    Findings:

    • Topical 5-fluorouracil (5-FU) demonstrated partial efficacy.
    • Despite treatment, new surrounding lesions continued to appear, indicating persistent disease activity.

    Implications:

    • This presentation highlights the aggressive and persistent nature of keratoacanthoma centrifugum marginatum.

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  • Effective long-term management strategies for this rare condition require further investigation.