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Oral controlled release dosage forms. A review.

P De Haan, C F Lerk

    Pharmaceutisch Weekblad. Scientific Edition
    |April 27, 1984
    PubMed
    Summary
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    Selecting appropriate oral controlled release dosage forms is crucial for prolonged therapeutic effects. This review examines galenical methods and physiological factors influencing drug delivery from these formulations available in the Dutch market.

    Area of Science:

    • Pharmaceutical Technology
    • Drug Delivery Systems
    • Pharmacokinetics

    Background:

    • Rational drug selection for controlled release necessitates appropriate dosage form design.
    • Oral controlled release products are widely available and utilized.

    Purpose of the Study:

    • To review galenical methods for controlling drug release in oral dosage forms.
    • To discuss the impact of physiological variables on drug delivery from these formulations.
    • To highlight formulation and design considerations for controlled release products.

    Main Methods:

    • Literature review of oral controlled release products on the Dutch market.
    • Analysis of galenical techniques for drug release modulation.
    • Examination of physiological factors affecting drug delivery.

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    Main Results:

    • Various galenical methods can achieve controlled drug release for prolonged therapeutic effects.
    • Physiological variables of the alimentary tract significantly influence drug delivery.
    • Formulation and dosage form design are critical for optimizing drug release profiles.

    Conclusions:

    • Proper selection of controlled release dosage forms is essential for effective therapy.
    • Understanding drug-formulation-physiology interactions is key to successful controlled release product development.
    • Galenical formulation and design play a vital role in achieving desired drug delivery outcomes.