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Related Experiment Videos

Controlled-release theophylline and proxyphylline in asthmatics: a comparative study.

H Mosbech, H Paulsen, M Søborg

    Pharmatherapeutica
    |January 1, 1984
    PubMed
    Summary

    A new sustained-release proxyphylline preparation showed no significant difference compared to theophylline or placebo in relieving asthma symptoms. Morning peak-flow was better with active treatments than with placebo.

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    Area of Science:

    • Pharmacology and Therapeutics
    • Respiratory Medicine

    Background:

    • Asthma management often involves bronchodilators.
    • Sustained-release formulations aim to improve patient adherence and efficacy.
    • Proxyphylline is a xanthine derivative used for respiratory conditions.

    Purpose of the Study:

    • To compare a new sustained-release proxyphylline preparation with theophylline and placebo in adult asthmatics.
    • To evaluate the efficacy and safety of sustained-release proxyphylline for asthma symptom relief.
    • To assess the impact on medication needs and side-effects.

    Main Methods:

    • Double-blind, crossover study design.
    • Inclusion of 10 adult participants with asthma.
    • Administration of proxyphylline (2400 mg/day), theophylline (800 mg/day), and placebo.

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  • Assessment of asthma symptom relief, additional medication use, and side-effects.
  • Measurement of morning peak expiratory flow rate.

    • Main Results:

    • No significant differences were observed between proxyphylline, theophylline, and placebo regarding asthma symptom relief.
    • Incidence and intensity of side-effects did not differ significantly across treatments.
    • Participants required similar amounts of additional medication regardless of treatment.
    • Morning peak expiratory flow rate was significantly lower during the placebo period compared to active treatment periods.

    Conclusions:

    • Sustained-release proxyphylline at 2400 mg/day demonstrated comparable efficacy to theophylline at 800 mg/day and placebo in this short-term study.
    • Active treatments, including sustained-release proxyphylline, showed a benefit in maintaining morning lung function compared to placebo.
    • Further research may be warranted to explore long-term effects and optimal dosing.