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Indium-111-labeled leukocyte localization in hematomas: a pitfall in abscess detection
Radiology
|July 1, 1984
Summary
Indium-111 labeled white blood cell scans are effective for abscess detection but can misidentify noninfected hematomas. This study highlights limitations in indium scanning specificity, particularly in certain patient groups.
Area of Science:
- Nuclear Medicine
- Diagnostic Imaging
- Radiopharmaceuticals
Background:
- Indium-111 labeled white blood cell (WBC) scanning is a widely adopted imaging technique for detecting abscesses.
- It offers high reported sensitivity and specificity, often surpassing gallium scanning.
Purpose of the Study:
- To evaluate the diagnostic accuracy and limitations of indium-111 labeled WBC scanning in abscess detection.
- To identify potential sources of false-positive results.
Main Methods:
- Retrospective analysis of seven cases with indium-111 labeled leukocyte uptake in noninfected hematomas.
- Histopathological and clinical course review to confirm the nature of the collections.
Main Results:
- Indium-111 labeled WBC scans showed uptake in seven cases of noninfected hematomas.
- These hematomas were characterized by abundant red blood cells, few WBCs, absence of bacteria, and benign clinical outcomes.
- A significant proportion of patients (5/7) were undergoing hemodialysis, and (3/7) were recent allograft recipients.
Conclusions:
- Indium-111 labeled WBC scanning, while beneficial, has limitations and can exhibit nonspecificity.
- Noninfected hematomas can present as false positives, necessitating careful interpretation, especially in immunocompromised patients or those on hemodialysis.