Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium blockers in smooth-muscle disorders. Current status.

M L Schwartz, H H Rotmensch, P H Vlasses

    Archives of Internal Medicine
    |July 1, 1984
    PubMed
    Summary

    Calcium-entry blockers effectively treat cardiovascular disorders. Preliminary research suggests these calcium antagonists show promise for managing noncardiac conditions involving smooth muscle dysfunction, warranting further clinical trials.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional tremor developing after successful MRI-guided focused ultrasound thalamotomy for essential tremor.

    Journal of neurology, neurosurgery, and psychiatry·2022
    Same author

    The duck, the desert rat, and the dichotomy.

    Postgraduate medicine·2016
    Same author

    Active MR-temperature feedback control of dynamic interstitial ultrasound therapy in brain: in vivo experiments and modeling in native and coagulated tissues.

    Medical physics·2014
    Same author

    The effect of amiodarone on theophylline pharmacokinetics in the rat.

    Pharmaceutical research·2013
    Same author

    The behavior of a newly described acute-phase protein in inflammatory joint disease.

    Inflammation·2013
    Same author

    Helping 'boat people'..

    Canadian family physician Medecin de famille canadien·2011

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Smooth Muscle Physiology

    Background:

    • Calcium-entry blockers are established treatments for cardiovascular diseases.
    • Their mechanism involves regulating ionic calcium flux, impacting smooth muscle contraction.

    Purpose of the Study:

    • To explore the potential of calcium antagonists in managing noncardiac conditions characterized by smooth muscle dysfunction.
    • To review existing therapeutic outcomes and identify areas for future research.

    Main Methods:

    • Review of existing literature on calcium-entry blocker efficacy.
    • Analysis of preliminary study results in noncardiac conditions.

    Main Results:

    • Proven efficacy in cardiovascular disorders.

    Related Experiment Videos

  • Beneficial results reported for hypertension and Raynaud's phenomenon.
  • Encouraging preliminary data for pulmonary hypertension, cerebral arterial spasm, migraine, esophageal motility disorders, and myometrial hypercontractile states.

    • Conclusions:

    • Calcium antagonists show therapeutic potential beyond cardiovascular applications.
    • Further large-scale, long-term clinical trials are necessary to confirm efficacy in noncardiac smooth muscle disorders.