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Collagen polymorphism in pathologic human scars.

L Weber, W N Meigel, W Spier

    Archives of Dermatological Research
    |February 15, 1978
    PubMed
    Summary
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    Pathologic scars show significantly increased type III collagen compared to normal skin, resembling fetal skin collagen composition. This finding aids in understanding scar tissue development and differences from healthy adult skin.

    Area of Science:

    • Biochemistry
    • Dermatology
    • Tissue Engineering

    Background:

    • Collagen types I and III are crucial components of dermal extracellular matrix.
    • Scar formation involves alterations in collagen composition and organization.
    • Understanding collagen differences in normal vs. pathologic scars is vital for regenerative medicine.

    Purpose of the Study:

    • To compare the collagen type I and III composition of normal skin, normal scars, and pathologic scars.
    • To investigate the relationship between collagen composition and scar maturity or pathology.
    • To identify distinct collagen profiles associated with different skin healing outcomes.

    Main Methods:

    • Tissue specimens were carefully separated into scar and adjacent normal dermis.

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  • Collagen was extracted using urea and cleaved with cyanogen bromide (CNBr).
  • Collagen types were identified and quantified via SDS-polyacrylamide gel electrophoresis of CNBr peptides.

    • Main Results:

    • Both collagen types I and III are present in normal skin, normal scars, and pathologic scars.
    • Older normal scars showed a slight increase in type III collagen.
    • Pathologic scars exhibited a significant increase in type III collagen compared to normal skin.
    • The CNBr peptide pattern of pathologic scars closely resembled that of fetal skin, differing from normal adult skin.

    Conclusions:

    • Pathologic scars have a distinct collagen type III enrichment, similar to fetal skin.
    • This altered collagen composition may contribute to the unique properties of pathologic scars.
    • The findings provide insights into the molecular basis of scar formation and potential therapeutic targets.