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Related Experiment Videos

Cimetidine for stress-ulcer prophylaxis.

W L Greene, R R Bollinger

    Critical Care Medicine
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Cimetidine is effective for preventing stress ulcers but offers no benefit over antacids. Combining cimetidine with antacids is not superior to using antacids alone for ulcer prophylaxis.

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Stress-induced ulcers are a common complication in critically ill patients.
    • Cimetidine and antacids are commonly used for prophylaxis.

    Purpose of the Study:

    • To compare the efficacy of cimetidine versus antacids for stress ulcer prophylaxis.
    • To evaluate the combined effect of cimetidine and antacids.

    Main Methods:

    • Review of comparative studies on stress ulcer prophylaxis.
    • Analysis of clinical trial data comparing cimetidine, antacids, and combination therapy.

    Main Results:

    • Cimetidine shows superiority over placebo for stress ulcer prophylaxis.
    • Cimetidine offers no significant advantage over titrated antacid dosing.

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  • Combination therapy with cimetidine and antacids is not more effective than full-dose antacids alone.

    • Conclusions:

    • Prophylactic cimetidine is recommended only when high-dose antacids are necessary to avoid acid-base disturbances.
    • Antacid therapy is a viable and effective alternative for stress ulcer prophylaxis.