Low-protein diet supplemented by keto acids in chronic renal failure: a prospective controlled study

In this prospective controlled study, a 30-g protein-restricted diet supplemented by keto acids resulted in a delayed rate of progression of chronic renal failure. The effect of this treatment differed according to the underlying renal disease. The rate of progression of chronic renal failure was delayed by a factor of at least 2. A need for long-term observations to quantify the effectiveness of this therapy is shown. A new pragmatic approach to the evaluation of long-term studies in patients with chronic renal failure is demonstrated.