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Updated: Aug 9, 2026
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The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
Published on: March 17, 2010
Summary
Inherited deficiencies in plasma protein C are strongly linked to recurrent venous thromboembolic disease. New functional assays promise deeper insights into protein C
Area of Science:
- Biochemistry
- Hematology
- Clinical Medicine
Background:
- Plasma protein C deficiency is clinically significant, with half-normal levels associated with venous thromboembolic disease.
- Severe homozygous protein C deficiency is life-threatening in infancy without treatment.
- The range of protein C deficiency includes abnormal molecules and reduced functional activity.
Purpose of the Study:
- To highlight the clinical importance of plasma protein C.
- To discuss the association between protein C levels and thrombotic events.
- To introduce the impact of new functional assays on understanding protein C's role.
Main Methods:
- Review of clinical data linking protein C levels to thrombosis.
- Discussion of inherited protein C deficiencies.
- Introduction of recent advancements in functional protein C assays.
Main Results:
- Strong association found between half-normal plasma protein C levels and recurrent venous thromboembolic disease.
- Identification of rare cases of young adults with thrombosis and protein C levels below 25%.
- Emerging data from new functional assays are beginning to provide insights.
Conclusions:
- Plasma protein C deficiency is a critical factor in venous thromboembolism.
- Advancements in functional assays are crucial for further research.
- New data will enhance understanding of protein C's role in thrombosis regulation.
