Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial amyloidosis. A histopathological study.

A Tanimura, T Cho, Y Shinohara

    Acta Pathologica Japonica
    |March 1, 1984
    PubMed
    Summary

    Familial amyloidosis primarily affects the nervous and endocrine systems, unlike other amyloidosis types. Autopsy findings reveal heavy amyloid fibril deposition in peripheral nerve interstices.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary abscess caused by Cladosporium cladosporioides after receiving outpatient chemotherapy.

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2023
    Same author

    Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.

    Scientific reports·2018
    Same author

    Isolation and characterization of dental epithelial cells derived from amelogenesis imperfecta rat.

    Oral diseases·2015
    Same author

    Temperature seasonality during fry out-migration influences the survival of hatchery-reared chum salmon Oncorhynchus keta.

    Journal of fish biology·2015
    Same author

    Working memory training is associated with lower prefrontal cortex activation in a divergent thinking task.

    Neuroscience·2013
    Same author

    Review: The role of autophagy in extravillous trophoblast function under hypoxia.

    Placenta·2013

    Area of Science:

    • Neuropathology
    • Genetics
    • Internal Medicine

    Background:

    • Familial amyloidosis is a rare genetic disorder characterized by amyloid protein deposition.
    • Understanding the specific tissue distribution and ultrastructural features is crucial for diagnosis and management.

    Observation:

    • Four autopsy cases of familial amyloidosis (3 male, 1 female; ages 37-51) presented with neurological symptoms.
    • Histological examination showed distinct amyloid deposition patterns compared to other amyloidosis types.
    • Electron microscopy focused on peripheral nervous tissue.

    Findings:

    • Familial amyloidosis demonstrated heavy amyloid deposition predominantly in the nervous and endocrine systems.
    • No significant differences in deposition were observed in other tissues.

    Related Experiment Videos

  • Massive amyloid fibril deposition was identified within the interstices of peripheral nerve fibers.

    • Implications:

    • These findings highlight the specific tropism of familial amyloidosis for neural and endocrine tissues.
    • The characteristic deposition pattern may aid in differentiating familial amyloidosis from other forms.
    • Further research into the molecular mechanisms driving this specific deposition is warranted.