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Related Experiment Videos

Extrapancreatic effects of a sulphonylurea. Decrease in xylose absorption by glipizide in type II diabetics.

M Kollind, U Adamson, P E Lins

    Acta Medica Scandinavica
    |January 1, 1984
    PubMed
    Summary

    Glipizide medication, used for type II diabetes, was found to lower blood glucose and xylose levels by stimulating insulin secretion. This suggests glipizide may also impact nutrient absorption mechanisms.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Gastroenterology

    Background:

    • Type II diabetes mellitus is characterized by impaired glucose regulation.
    • Glipizide is a sulfonylurea medication commonly prescribed to manage hyperglycemia.
    • The impact of glipizide on gastrointestinal absorption requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of glipizide on glucose and d-xylose absorption in type II diabetic patients.
    • To compare the influence of intravenous versus oral glipizide administration on these parameters.

    Main Methods:

    • Six type II diabetic patients on diet alone were enrolled.
    • Glipizide was administered intravenously (12 mcg/kg) or orally (5 mg).
    • Oral glucose (15 g) and d-xylose (25 g) loads were administered concurrently.

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    Main Results:

    • Glipizide significantly reduced both glucose and xylose levels via both administration routes.
    • Insulin secretion was stimulated by glipizide.
    • The suppressive effect on xylose levels was more prolonged following oral administration compared to intravenous.

    Conclusions:

    • Glipizide influences postprandial glucose levels not only through insulin secretion but potentially by interfering with intestinal absorption mechanisms.
    • Oral administration of glipizide may have a more sustained impact on absorption than intravenous.
    • Further research into glipizide's absorptive effects is warranted.