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Caffeine and hypertension.

D Robertson, A S Hollister, D Kincaid

    The American Journal of Medicine
    |July 1, 1984
    PubMed
    Summary
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    This study found that prolonged caffeine intake did not significantly elevate blood pressure or related markers in hypertensive individuals. Short-term caffeine use may cause minor, temporary blood pressure increases.

    Area of Science:

    • Cardiovascular Pharmacology
    • Clinical Hypertension Research

    Background:

    • Hypertension is a significant global health concern.
    • Caffeine is a widely consumed stimulant with potential cardiovascular effects.
    • Understanding caffeine's impact on blood pressure in hypertensive patients is crucial.

    Purpose of the Study:

    • To investigate the long-term effects of caffeine administration on blood pressure.
    • To assess changes in plasma catecholamine levels and plasma renin activity.
    • To evaluate caffeine's safety and efficacy in managing blood pressure in hypertensive subjects.

    Main Methods:

    • A double-blind, placebo-controlled study design.
    • Eighteen hypertensive subjects received either placebo or caffeine (250 mg three times daily) for seven days.

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  • Blood pressure, plasma catecholamine, and plasma renin activity were monitored.

    • Main Results:

    • A transient, non-significant increase in systolic blood pressure was observed after the initial caffeine dose.
    • No significant long-term elevations in systolic or diastolic blood pressure were noted.
    • Plasma catecholamine levels and plasma renin activity showed no significant changes.

    Conclusions:

    • Prolonged caffeine administration does not lead to significant sustained increases in blood pressure in hypertensive patients.
    • Caffeine appears safe for individuals with borderline hypertension regarding blood pressure and key hormonal markers.
    • No adverse cardiovascular events or significant hormonal alterations were observed during the study period.