The relationship between ethanol-induced locomotor activation and narcosis in long-sleep and short-sleep mice

Mice selectively bred for marked response to hypnotic doses of ethanol (long-sleep, LS) respond to subhypnotic doses of ethanol (ETOH) with less stimulation of locomotor activity than their short-sleep (SS) counterparts. This assessment was made by comparing ETOH-induced alterations in locomotor activity to an untreated baseline within individual subjects, and to a saline-treated control group. A correlational study, using the same method in F2 generation hybrids of the LS and SS lines, produced a negative correlation (-.36) between locomotor stimulant effects of a subhypnotic dose of ETOH and length of loss of the righting reflex following a hypnotic dose. This relationship also appeared in a factor analysis of baseline locomotor activity, ETOH-stimulated activity, and depressant response variables. The genetic selection for LS and SS mice appears to have differentiated loci that influence more than one type of behavioral response to ETOH, an example of pleiotropism.